An exceptional architectural ranch in Rochester's historic Pill Hill neighborhood, this completely reimagined four-bedroom, four-bath residence blends the character of old southwest Rochester with modern luxury and smart home integration just two blocks from Mayo Clinic Hospital, Saint Marys Campus and minutes from downtown. While the exterior preserves the architectural presence of the original residence, which itself is a part of Mayo history, the interior underwent a comprehensive architect-led studs-out renovation in 2019. Designed for main-floor ease, the home features a bright open layout, walkout lower level, and attached heated two-car garage. Sophisticated finishes throughout include hickory hardwood floors, Calacatta marble, custom cherry cabinetry, copper gutters and valleys, Ortal three-sided fireplaces, and thoughtfully integrated smart home features. The walkout lower level offers exceptional flexibility with two additional bedrooms, two bathrooms, full second kitchen, and generous sun-filled entertaining space ideal for guests or multi-generational living. A truly unique blend of Rochester history, architectural character, and modern executive living.