An iconic historic opportunity has arrived. Introducing The Bissell House, South Pasadena Cultural Landmark #39, a distinguished 1887 Queen Anne Victorian estate featuring EIGHT PRIMARY suites and 10 baths in 5,535 sf, per assessor. Formerly operated as a B&B, this grand dame offers exceptional flexibility, including a dual kitchen configuration ideal for extended living or hospitality use. A grand entrance and wraparound veranda make an immediate statement, leading to a dramatic grand staircase and a richly appointed library, while stunning original details remain intact, including Tiffany stained glass windows, Edwardian clawfoot tubs, intricate woodwork throughout, and an elevator. The home also features a substantial 1,230 sf basement providing extensive storage, a separate 231 sf bonus room adjacent to the two-car garage, and multiple living spaces ideal for private or guest use. Set on an expansive and flat 22,671 sf lot, per assessor, framed by mature trees and palms, the grounds create a private estate setting rarely found in South Pasadena and include a pool and spa, terrace, and poolhouse. Zoned residential R-E (Residential Estate) with the potential as a family compound, ADU and Junior ADU configurations, hospitality use, student housing, care facility, or other adaptive possibilities that may require a conditional use permit (CUP). Buyers should verify with the City of South Pasadena. Conveniently located close to Pasadena, Huntington Hospital, and a straight shot to USC via the 110 freeway, few properties offer this combination of pedigree, scale, flexibility, and long-term upside in such a premier setting.