21 Great Island Road offers a perfect blend of natural beauty, modern system upgrades, and the quintessential Cape Cod lifestyle. Boasting stunning marsh views, access to neighborhood conservation trails, and easy proximity to multiple beaches, this home is an exceptional opportunity for those seeking privacy, comfort, and recreation. Set on a spacious 2.36-acre lot, this well-maintained Colonial features 4 bedrooms, 3 full bathrooms, a 2-car garage, and nearly 2,800 sq ft of living space — ideal for comfortable year-round or seasonal living. Enjoy easy access to both East Sandwich Beach and Sandy Neck Beach, just minutes away — perfect for boating, beach-combing, and coastal adventures. Quality upgrades include a new roof (2022), boiler (2015), central air (2015), and a whole-house generator, making this home ready for worry-free living with no flood insurance required. High ceilings and spacious rooms provide ample space to personalize with your own cosmetic touches. Nestled in a peaceful, private spot tucked away north of Route 6A, this is Cape Cod living at its finest.